A while ago I blogged about my new Pre-workout, which was Hydracetam. Basically, Aniracetam paired with Alpha-GPC and Huperzine-A.
I have since made some beneficial changes to it, should save everybody some money. Below are the changes, and my reasoning for it.
Basically, drop the Huperzine-A
Looking over Huperzine-A’s involvement in the stack, a few things stuck out at me:
- It has a very long half-life
- It acts on an important enzyme (acetylcholinesterase)
- It seems to be clinically significant (effective) in models of cognitive impairment, but not potent enough by itself to be effective in healthy persons
In regards to the last bullet, I initially included it in the stack due to its safety profile and the fact that although studies in isolation aren’t that promising perhaps it could be better with the Alpha-GPC? Since then, I’ve rescinded this thought.
This isn’t to say Huperzine-A is dangerous; it isn’t. It has a good safety profile in clinical studies in healthy persons (usually elderly persons, and usually cognitive deficits). That being said, acute toxicity (of which it pretty much doesn’t exist) is different from long term yet subtle changes in enzyme levels.
Its theoretical that inhibiting acetylcholinesterase would cause a gradual increase in enzyme levels, which brings more basal degradation of acetylcholine (ie. less learning neurotransmitter without Huperzine-A). There really isn’t any conclusive evidence on either side of the equation here, but I’m going to be playing it safe.
Short term usage of Huperzine-A shouldn’t be too bad, so if you have a bottle on hand then its fine to finish it off. Its just with the large AUC and long half-life giving the body little to no downtime from the stressor (unlike Alpha-GPC and Aniracetam, both of which are cleared from the blood a few hours after ingestion) its not something I would want to continue recommending to people who I cannot personally modify their supplement routines. A pre-workout shouldn’t be floating around in your body for an entire day, it should be in and out after its done its job.
In sum; drop the Huperzine-A and save some money. Its the least important of the three compounds, and at the current dosage its not the best thing to take continually for a long time (and a lower dose is unlikely to do jack shit in healthy young athletes).
(Additionally, I do like to use basic stimulants like ephedrine or caffeine with Hydracetam; works nicely and has better kinetics)